No landings or take-offs were allowed after a drone was spotted over the southern part of the airport area in the early morning, but the all clear was given shortly after 8.15am at Germany’s busiest airport.
The aviation authority said 143 take-offs and landings were cancelled and 48 aircraft already in the air were diverted to other airports among a total of 1,500 scheduled flights on Thursday.
Several passengers had to wait in planes while the sighting was investigated.
The drone, which was approximately 1.5 metres in diameter, was spotted by several pilots.
Police are investigating and a helicopter tried to track the remote-controlled device after the latest drone incident to disrupt flights at the airport.
Police were at the scene investigating the incident. They tweeted to say flight operations had resumed at 8.18am.